GLI2-Specific Recombinant monoclonal antibody proteintech 84141-1-RR
$449.00
In stock
SKU
84141-1-RR
Gli2, Tax helper protein, GLI Kruppel family member GLI2, Gli 2, AW546128
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human, mouse | Immunogen: GLI family zinc finger 2 |
| Applications: WB, IF/ICC, ELISA | Observed Molecular Weight: 80-90 kDa, 130-140 kDa, 160-180 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: GLI2 |
| Conjugate: Unconjugated | Gene Symbol: 2736 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): AB_3671702 |
| Application: Western Blot (WB) | RRID: Unconjugated |
| Dilution: WB : 1:5000-1:50000 | Conjugate: Liquid |
| Tested Reactivity: Human, Mouse | Form: Protein A purfication |
| Host / Isotype: Recombinant | Background Information: GLI2, also named as THP, belongs to the GLI C2H2-type zinc-finger protein family. GLI2 play a role during embryogenesis. It binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the TRE-2S regulatory element that augments the Tax-dependent enhancer of human T-cell leukemia virus type 1. It is implicated in the transduction of SHH signal. Mutation of GLI2 will cause of holoprosencephaly type 9 (HPE9). Four possible isoforms (hGli2a, b, g, and d) are formed by combinations of two independent alternative splicings, and all the isoforms could bind to a DNA motif, TRE2S. hGli2 a, b, g, and d. These isoforms encode 133-, 131-, 88-, and 86-kDa proteins, respectively. |
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