FKBP5 Recombinant monoclonal antibody proteintech 86189-2-RR
$449.00
In stock
SKU
86189-2-RR
FKBP-51, 51 kDa FK506-binding protein, 54 kDa progesterone receptor-associated immunophilin, AIG6, Androgen-regulated protein 6
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human | Immunogen: FK506 binding protein 5 |
| Applications: WB, IF/ICC, ELISA | Observed Molecular Weight: 51 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: FKBP5 |
| Conjugate: Unconjugated | Gene Symbol: 2289 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): Unconjugated |
| Application: Western Blot (WB) | RRID: Liquid |
| Dilution: WB : 1:2000-1:10000 | Conjugate: Protein A purification |
| Tested Reactivity: Human | Form: Q13451 |
| Host / Isotype: Recombinant | Background Information: FKBP5, also known as FKBP51, belongs to the family of immunophilins, FK506 binding proteins (FKBPs). FKBP5 is a negative regulator of GR activity and plays a key role in the termination of the stress response by GRs. FKBP5 limits GR function by decreasing ligand-binding sensitivity, thereby delaying nuclear translocation and reducing GR-dependent transcriptional activity. The known functions of FKBP5 include the regulation of steroid hormone receptors, inhibiting apoptosis in cancer cells, promoting Akt1 dephosphorylation, and inhibiting the Akt1 pathways, to name a few. FKBP5 is widely expressed and the calculated molecular weight is 51 kDa (PMID: 21119664, PMID:?34077736, PMID: 37154033). |
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