DSG1 Recombinant monoclonal antibody proteintech 84053-6-RR
$449.00
In stock
SKU
84053-6-RR
Desmosomal glycoprotein 1, Desmoglein-1, desmoglein 1, CDHF4, Cadherin family member 4
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human, rat | Immunogen: desmoglein 1 |
| Applications: WB, IHC, ELISA | Observed Molecular Weight: 160 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: DSG1 |
| Conjugate: Unconjugated | Gene Symbol: 1828 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): AB_3671621 |
| Application: Western Blot (WB) | RRID: Unconjugated |
| Dilution: WB : 1:5000-1:50000 | Conjugate: Liquid |
| Tested Reactivity: Human, Rat | Form: Protein A purfication |
| Host / Isotype: Recombinant | Background Information: Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmosomal cadherins, consisting of four desmogleins (DSG1-4) and three desmocollins (DSC1-3) in humans, mediate adhesion through calcium-dependent homophilic/heterophilic interactions. DSG1 is a single-pass transmembrane glycoprotein highly expressed in the epidermis and localized primarily within the suprabasal epithelial layers (PMID: 16286477; 24220297). DSG1 mediates intercellular adhesion and is crucial in maintaining epidermal integrity and barrier function (PMID: 23974871). It is also involved in epithelial cell differentiation (PMID: 23524961). Mutations in the DSG1 gene can cause the autosomal dominant disorder to striate palmoplantar keratoderma and a syndrome featuring severe dermatitis, multiple allergies, and metabolic wasting (SAM syndrome) (PMID: 29315490; 23974871). |
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