ADAMTS4 Recombinant monoclonal antibody proteintech 82744-2-RR
$449.00
In stock
SKU
82744-2-RR
ADAM-TS 4, ADAMTS 4, ADAM TS4, ADAM TS 4, A disintegrin and metalloproteinase with thrombospondin motifs 4
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human, mouse, rat | Immunogen: ADAM metallopeptidase with thrombospondin type 1 motif, 4 |
| Applications: WB, FC (Intra), ELISA | Observed Molecular Weight: 90 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: ADAMTS4 |
| Conjugate: Unconjugated | Gene Symbol: 9507 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): AB_3670543 |
| Application: Western Blot (WB) | RRID: Unconjugated |
| Dilution: WB : 1:1000-1:5000 | Conjugate: Liquid |
| Tested Reactivity: Human, Mouse, Rat | Form: Protein A purification |
| Host / Isotype: Recombinant | Background Information: The ADAMTS (a disintegrin-like and metalloproteinase with thrombospondin motifs) is a family of extracellular metalloproteinases mediating diverse functions including matrix degradation, blood coagulation and angiogenesis. The ADAMTS family constitutes a group of proteins composed of 19 enzymes and 7 ADAMTS-like proteins. ADAMTS4 is a well-known proteoglycanase and has angiomodulatory properties. The 837 amino acid long human ADAMTS4 protein contains a long signal peptide, a prodomain, a metalloproteinase catalytic domain with zinc-binding motif, a disintegrin-like domain, a central TSR motif, followed by a cysteine-rich region with ten conserved cysteine residues, and a spacer domain. The full-length proform human ADAMTS4 (zymogen form) has been described to be 90 kDa. In extracellular matrix (ECM), ADAMTS4 undergoes further C-terminal cleavage at Lys694-Phe695 and Thr581-Phe582, respectively, to generate two other truncated forms-53 and 40 kDa (PMID:12202483). |
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