FBXO38 Recombinant monoclonal antibody proteintech 83509-6-RR
$449.00
In stock
SKU
83509-6-RR
SP329, MOKA, Fbx38, F box protein 38, F box only protein 38
| Host / Isotype: Rabbit / IgG | Class: Recombinant |
| Reactivity: Human And More (1) | Immunogen: CatNo: Ag35444 Product name: Recombinant human FBXO38 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 490-700 aa of XM_005268513.1 Sequence: SNQNSNNDDNNAQNNNANIHDNNHHHPDDSDEENDFRQDLQPGEQQFAADALNEMEDIVQEDGEVVAESGNNTPAHSQAIIPVDVDEEQAGPSGLQRVVKPTSITVHDSESDDEEDSLELQEVWIPKNGTRRYSEREEKTGESVQSRELSVSGKGKTPLRKRYNSHQMGQSKQFPLEESSCEKGCQVTSEQIKADMKAARDIPEKKKNKDV Predict reactive species |
| Applications: WB, ELISA | Observed Molecular Weight: 134kDa，1188aa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: XM_005268513.1 |
| Conjugate: Unconjugated | Gene Symbol: FBXO38 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 81545 |
| Application: Western Blot (WB) | RRID: AB_3671134 |
| Dilution: WB : 1:1000-1:6000 | Conjugate: Unconjugated |
| Tested Reactivity: Human | Form: Liquid |
| Host / Isotype: Rabbit / IgG | Background Information: FBXO38, also known as HMN2D, MOKA, and SP329, is a protein that plays a significant role in the regulation of immune responses, particularly in the context of cancer and autoimmune diseases. FBXO38 has been identified as an E3 ubiquitin ligase that mediates the degradation of PD-1 (Programmed cell death protein 1), a key immune checkpoint protein expressed on the surface of T cells. The internalization, ubiquitination, and proteasome degradation of PD-1 are facilitated by FBXO38, which links PD-1 to Lys48, leading to its poly-ubiquitination and subsequent degradation (PMID: 30487606). |
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