SMN Recombinant monoclonal antibody proteintech 86668-2-RR
$449.00
In stock
SKU
86668-2-RR
C BCD541, Component of gems 1, Gemin 1, Gemin-1, SMN1
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human, mouse, rat | Immunogen: survival of motor neuron 2, centromeric |
| Applications: WB, IF/ICC, IP, ELISA | Observed Molecular Weight: 38 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: SMN |
| Conjugate: Unconjugated | Gene Symbol: 6607 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): Unconjugated |
| Application: Western Blot (WB) | RRID: Liquid |
| Dilution: WB : 1:1000-1:4000 | Conjugate: Protein A purification |
| Tested Reactivity: Human, Mouse, Rat | Form: Q16637 |
| Host / Isotype: Recombinant | Background Information: Spinal muscular atrophy (SMA) is an autosomal recessive neurodegenerative disease characterized by loss of anterior horn cells in the spinal cord and concomitant symmetrical muscle weakness and atrophy (PMID: 16364894 ). SMA is caused by deletion or mutations of the survival motor neuron (SMN1) gene. SMA patients lack a functional SMN1 gene, but they possess an intact SMN2 gene, which though nearly identical to SMN1, is only partially functional (PMID: 17355180). A large majority of SMN2 transcripts lack exon 7, resulting in production of a truncated, less stable SMN protein (PMID: 10369862). The level of SMN protein correlates with phenotypic severity of SMA. |
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