SIRT1 Recombinant monoclonal antibody proteintech 82790-4-RR
$449.00
In stock
SKU
82790-4-RR
2F11, EC:2.3.1.-, EC:2.3.1.286, hSIR2, hSIRT1
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human | Immunogen: sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) |
| Applications: WB, IHC-Autostainer, IF/ICC, IP, ELISA | Observed Molecular Weight: 110-130 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: SIRT1 |
| Conjugate: Unconjugated | Gene Symbol: 23411 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): AB_3086537 |
| Application: Western Blot (WB) | RRID: Unconjugated |
| Dilution: WB : 1:1000-1:8000 | Conjugate: Liquid |
| Tested Reactivity: Human | Form: Protein A purification |
| Host / Isotype: Recombinant | Background Information: SIRT1, also named as SIR2L1, contains a deacetylase sirtuin-type domain and belongs to the sirtuin family. The post-translation modified SIRT1 is a 110-130 kDa protein, which contains one deacetylase sirtuin-type domain. The 75-80 kDa SirT1 fragment was detected to lack the carboxy-terminus (PMID:21305533). SirT1 exists a 57-61 kDa isoform. SIRT1 may be found in nucleolus, nuclear euchromatin, heterochromatin, and inner membrane. It can shuttles between the nucleus and cytoplasm. SIRT1 regulates processes such as apoptosis and muscle differentiation by deacetylating key proteins. SIRT1 in particular initiates several signaling events relevant to cardioprotection, including activation of endothelial nitric oxide synthase, INS receptor signaling, and autophagy. In addition, SIRT1 activation elicits resistance to oxidative stress via the regulation of transcription factors and co-activators such as FOXO, Hif-2a, and NF-kB. SIRT1 regulates the p53-dependent DNA damage response pathway by binding to and deacetylating p53, specifically at Lysine 382. |
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