ATF4 Recombinant monoclonal antibody proteintech 81798-1-RR
$449.00
In stock
SKU
81798-1-RR
5N3, cAMP-dependent transcription factor ATF-4, CREB2, Cyclic AMP-responsive element-binding protein 2, Tax-responsive enhancer element-binding protein 67
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human, mouse | Immunogen: activating transcription factor 4 (tax-responsive enhancer element B67) |
| Applications: WB, IHC, IP, ELISA, ChIP-qPCR | Observed Molecular Weight: 50 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: ATF4 |
| Conjugate: Unconjugated | Gene Symbol: 468 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): AB_2935580 |
| Application: Western Blot (WB) | RRID: Unconjugated |
| Dilution: WB : 1:5000-1:50000 | Conjugate: Liquid |
| Tested Reactivity: Human, Mouse | Form: Protein A purification |
| Host / Isotype: Recombinant | Background Information: ATF4 is a transcription factor, that accumulates predominantly in osteoblasts, where it regulates terminal osteoblast differentiation and bone formation[PMID: 19016586]. As a basic leucine-zipper (bZip) transcription factor, ATF4 can regulate amino acid metabolism, cellular redox state, and anti-stress responses. It also regulates age-related and diet-induced obesity and glucose homeostasis in mammals, and has conserved metabolic functions in flies[PMID: 19726872]. Due to its location at chromosome 22q13, a region linked to schizophrenia, ATF4 is considered as a positional candidate gene for schizophrenia[PMID: 18163433]. Otherwise, since ATF4 is induced by tumour microenvironmental factors, and regulates processes relevant to cancer progression, it might serve as a potential therapeutic target in cancer. Endogenous ATF4 protein has a molecular mass of 50kd. [PMID: 17726049]. ATF4 can bind DNA as a homodimer and as a heterodimer. ATF4 is ubiquitinated by SCF(BTRC) in response to mTORC1 signal, followed by proteasomal degradation and leading to down-regulate expression of SIRT4, so the molecular weight of ATF4 may be 70 kDa. |
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