ABCC5 Recombinant monoclonal antibody proteintech 84204-5-RR
$449.00
In stock
SKU
84204-5-RR
MRP5, MOAT C, EC:7.6.2.-, ATP-binding cassette sub-family C member 5, ABCC 5
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human | Immunogen: ATP-binding cassette, sub-family C (CFTR/MRP), member 5 |
| Applications: WB, IHC, IF/ICC, ELISA | Observed Molecular Weight: 161-200 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: ABCC5 |
| Conjugate: Unconjugated | Gene Symbol: 10057 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): AB_3671760 |
| Application: Western Blot (WB) | RRID: Unconjugated |
| Dilution: WB : 1:1000-1:6000 | Conjugate: Liquid |
| Tested Reactivity: Human | Form: Protein A purfication |
| Host / Isotype: Recombinant | Background Information: ABCC5, also named MOAT-C, pABC11, SMRP, and MRP5, belongs to the ABC transporter superfamily, ABCC family, and Conjugate transporter (TC 3.A.1.208) subfamily. ABCC5 acts as a multispecific organic anion pump that can transport nucleotide analogs. ABCC5 functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that ABCC5 provides resistance to thiopurine anticancer drugs, 6-mercaptopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl) adenine. ABCC5 may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site are unclear. Since it is glycosylated, the apparent molecular weight of ABCC5 could be variable, ranging from 161 kDa to 200 kDa (PMID: 10893247; PMID: 15897250; PMID: 31338999). |
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