Phospho-ULK1 (Ser556) Recombinant monoclonal antibody proteintech 80218-1-RR
$449.00
In stock
SKU
80218-1-RR
p ULK1, p ULK1 (Ser556), p ULK1 Ser556, Phospho ULK1, Phospho ULK1 (Ser556)
| Host / Isotype: Rabbit / IgG | Class: Recombinant |
| Reactivity: Human And More (3) | Immunogen: Peptide Predict reactive species |
| Applications: WB, IHC, IF, FC (Intra), ELISA | Observed Molecular Weight: 140 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: ULK1 |
| Conjugate: Unconjugated | Gene Symbol: 8408 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): AB_2918877 |
| Application: Western Blot (WB) | RRID: Unconjugated |
| Dilution: WB : 1:2000-1:10000 | Conjugate: Liquid |
| Tested Reactivity: Human | Form: Protein A purification |
| Host / Isotype: Rabbit / IgG | Background Information: Unc-51-like-kinase 1 (ULK1) is a target of both the mechanistic target of rapamycin (mTOR) and AMP activated protein kinase (AMPK), whose role is to facilitate the initiation of autophagy in response to starvation. ULK1 is phosphorylated on serine 638 and 758 sites by mTOR in nutrient-rich conditions, inhibiting ULK1 activation by disrupting its binding to AMPK. Upon glucose starvation, dissociation of mTOR from ULK1 and phosphorylation by AMPK leads to the activation of ULK1 activity. The S556 site of ULK1 is one of the major AMPK-dependent phosphorylation sites. (PMID:?30517873, PMID:?21258367) |
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