IRF8 Monoclonal antibody proteintech 67142-1-Ig
$449.00
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67142-1-Ig
| Host / Isotype: Mouse / IgG2b | Class: Monoclonal |
| Reactivity: human | Immunogen: CatNo: Ag19909 Product name: Recombinant human IRF8 protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 121-426 aa of BC126247 Sequence: KLGVATAGCVNEVTEMECGRSEIDELIKEPSVDDYMGMIKRSPSPPEACRSQLLPDWWAQQPSTGVPLVTGYTTYDAHHSAFSQMVISFYYGGKLVGQATTTCPEGCRLSLSQPGLPGTKLYGPEGLELVRFPPADAIPSERQRQVTRKLFGHLERGVLLHSSRQGVFVKRLCQGRVFCSGNAVVCKGRPNKLERDEVVQVFDTSQFFRELQQFYNSQGRLPDGRVVLCFGEEFPDMAPLRSKLILVQIEQLYVRQLAEEAGKSCGAGSVMQAPEEPPPDQVFRMFPDICASHQRSFFRENQQITV Predict reactive species |
| Applications: WB, IF/ICC, CoIP, ELISA | Observed Molecular Weight: 426 aa, 48 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC126247 |
| Conjugate: Unconjugated | Gene Symbol: IRF8 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 3394 |
| Application: Western Blot (WB) | RRID: AB_2882441 |
| Dilution: WB : 1:1000-1:6000 | Conjugate: Unconjugated |
| Tested Reactivity: Human | Form: Liquid |
| Host / Isotype: Mouse / IgG2b | Background Information: IRF8 also named as ICSBP1, is a transcription factor of the IFN regulatory factor (IRF) family. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection. IRF8 specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the IFN consensus sequence (ICS)). It plays a negative regulatory role in cells of the immune system. It is predominantly in lymphoid tissues. |
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