PHEX Monoclonal antibody proteintech 66934-1-Ig
$449.00
In stock
SKU
66934-1-Ig
1D4B2, EC:3.4.24.-, HPDR, HYP1, PEX
| Host / Isotype: Mouse / IgG1 | Class: Monoclonal |
| Reactivity: human, rat, pig | Immunogen: CatNo: Ag20290 Product name: Recombinant human PHEX protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 41-391 aa of BC105059 Sequence: SQGLLSLQAKQEYCLKPECIEAAAAILSKVNLSVDPCDNFFRFACDGWISNNPIPEDMPSYGVYPWLRHNVDLKLKELLEKSISRRRDTEAIQKAKILYSSCMNEKAIEKADAKPLLHILRHSPFRWPVLESNIGPEGVWSERKFSLLQTLATFRGQYSNSVFIRLYVSPDDKASNEHILKLDQATLSLAVREDYLDNSTEAKSYRDALYKFMVDTAVLLGANSSRAEHDMKSVLRLEIKIAEIMIPHENRTSEAMYNKMNISELSAMIPQFDWLGYIKKVIDTRLYPHLKDISPSENVVVRVPQYFKDLFRILGSERKKTIANYLVWRMVYSRIPNLSRRFQYRWLEFSR Predict reactive species |
| Applications: WB, IHC, ELISA | Observed Molecular Weight: 749 aa, 86 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC105059 |
| Conjugate: Unconjugated | Gene Symbol: PHEX |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 5251 |
| Application: Western Blot (WB) | RRID: AB_2882259 |
| Dilution: WB : 1:500-1:3000 | Conjugate: Unconjugated |
| Tested Reactivity: Human, Rat, Pig | Form: Liquid |
| Host / Isotype: Mouse / IgG1 | Background Information: PHEX encodes a transmembrane endopeptidase that belongs to the type II integral membrane zinc-dependent endopeptidase family. The protein usually expressed in osteocytes, osteoblasts and odontoblasts, and it was thought to be involved in bone and dentin mineralization and renal phosphate reabsorption (PMID:28982589). Otherwise, studies showed that PHEX?transcripts were identified in human osteosarcoma-derived cells and in differentiated mouse osteoblasts, but not in immature mouse preosteoblasts, indicating the stage-specific expression of the protein (PMID:9199999). Defects in?PHEX?are responsible for X-linked hypophosphatemic rickets (HYP) (PMID:22339660). Glycosylation of proteins results in higher molecular weight, and about 95-100 kDa band were reported (PMID:25128529; PMID:18728349). |
Reviews
Write Your Own Review
Related Products
Check items to add to the cart or
