NeutraControl IL-10 Mouse McAb proteintech 69518-1-Ig
$189.00
In stock
SKU
69518-1-Ig
CSIF, IL 10, IL10, IL-10, IL10A, interleukin 10, TGIF
| Host / Isotype: Mouse / IgG1 | Class: Monoclonal |
| Reactivity: Human And More (1) | Immunogen: CatNo: Product name: HumanKine? recombinant human IL-10 protein Source: -derived, Tag: Domain: of Sequence: Predict reactive species |
| Applications: WB, ELISA, Non-Neutralization | Observed Molecular Weight: IL-10 |
| Formulation: Sterile PBS | GenBank Accession Number: AB_2918852 |
| Conjugate: Unconjugated | Gene Symbol: Unconjugated |
| Gene ID (NCBI): Lyophilized Powder | |
| RRID: Protein G purification | |
| Conjugate: P22301 | |
| Tested Reactivity: Human | Form: Sterile PBS, pH 7.4. |
| Host / Isotype: Mouse / IgG1 | Background Information: The human IL10 gene is 4.7 kb in size and is located on the long arm of chromosome 1. It contains five exons. Biologically functional IL-10 exists in the form of a 36 kDa homodimer composed of two non-covalently bonded mono-mers each with 160 amino acids length. IL-10 is an anti-inflammatory cytokine, produced by T helper (Th) cells, macrophages, monocytes, and B cells, that plays a crucial role in preventing inflammatory and autoimmune pathologies. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-κB activity, and is involved in the regulation of the JAK-STAT signaling pathway. IL-10, along with its receptors, describes an important role in pathogenesis of various diseases, including infectious, inflammatory, autoimmune diseases. IL-10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. This antibody is a neutralizing control antibody for IL-10, the immunogen is the same as Neutrakine 69018-1-Ig but could not neutralize human IL-10. |
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