TRAIL/CD253 Monoclonal antibody proteintech 66756-1-Ig
$449.00
In stock
SKU
66756-1-Ig
TNFSF10, TRAIL, 1B9B4, Apo-2 ligand, CD253
| Host / Isotype: Mouse / IgG1 | Class: Monoclonal |
| Reactivity: human | Immunogen: CatNo: Ag25746 Product name: Recombinant human TRAIL protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 39-281 aa of BC032722 Sequence: TNELKQMQDKYSKSGIACFLKEDDSYWDPNDEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPLVRERGPQRVAAHITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEKGFYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTSYPDPILLMKSARNSCWSKDAEYGLYSIYQGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLVG Predict reactive species |
| Applications: WB, IHC, IF, ELISA | Observed Molecular Weight: 281 aa, 33 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC032722 |
| Conjugate: Unconjugated | Gene Symbol: TRAIL |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 8743 |
| Application: Western Blot (WB) | RRID: AB_2882102 |
| Dilution: WB : 1:500-1:2000 | Conjugate: Unconjugated |
| Tested Reactivity: Human | Form: Liquid |
| Host / Isotype: Mouse / IgG1 | Background Information: TNFSF10/TRAIL (tumor necrosis factor superfamily member 10) is a typical death ligand expressed on natural killer cells and cytotoxic T lymphocytes. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. TNFSF10 induces apoptotic cell death in cancer by binding to its functional death receptors, death receptor (DR) 4 (TNFRSF10A/TRAIL-R1) and DR5 (TNFRSF10B/TRAIL-R2) to activate the extrinsic apoptosis pathway. TRAIL also activates c-Jun N-terminal kinase (MAPK8/JNK) and the transcription factor nuclear factor-κB (NFκB). The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. |
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