SLC7A5 Monoclonal antibody proteintech 67951-1-Ig
$449.00
In stock
SKU
67951-1-Ig
LAT1, 2G5H3, 4F2 LC, 4F2 light chain, 4F2LC
| Host / Isotype: Mouse / IgG2b | Class: Monoclonal |
| Reactivity: Human And More (1) | Immunogen: CatNo: Ag20291 Product name: Recombinant human SLC7A5 protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 300-507 aa of BC039692 Sequence: LSTEQMLSSEAVAVDFGNYHLGVMSWIIPVFVGLSCFGSVNGSLFTSSRLFFVGSREGHLPSILSMIHPQLLTPVPSLVFTCVMTLLYAFSKDIFSVINFFSFFNWLCVALAIIGMIWLRHRKPELERPIKVNLALPVFFILACLFLIAVSFWKTPVECGIGFTIILSGLPVYFFGVWWKNKPKWLLQGIFSTTVLCQKLMQVVPQET Predict reactive species |
| Applications: WB, IF, ELISA | Observed Molecular Weight: 507 aa, 55 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC039692 |
| Conjugate: Unconjugated | Gene Symbol: SLC7A5 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 8140 |
| Application: Western Blot (WB) | RRID: AB_2918703 |
| Dilution: WB : 1:5000-1:50000 | Conjugate: Unconjugated |
| Tested Reactivity: Human | Form: Liquid |
| Host / Isotype: Mouse / IgG2b | Background Information: Large neutral amino acid transporter 1 LAT1(also named as SLC7A5) is a sodium- and pH-independent transporter that supplies essential amino acids (e.g., leucine, phenylalanine) to cells. It plays an important role in the blood-brain barrier (BBB), where it facilitates the transport of thyroid hormones, drugs (e.g., l-DOPA, gabapentin), and metabolites to the brain. In addition, its expression is highly upregulated in various types of human cancers, which are characterized by a high demand for amino acids for growth and proliferation. The LAT1 subunit in humans is a 507 amino acid-long polypeptide with a theoretical molecular mass of 55 kDa. The protein is hydrophobic and is predicted to be constituted by 12 transmembrane segments. The apparent molecular mass of the proteins diminished to approximately 35 - 40 kDa.(PMID: 23912240 ;PMID: 26256001) |
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