RICTOR Monoclonal antibody proteintech 66867-2-Ig
$449.00
In stock
SKU
66867-2-Ig
1D1C4, AVO3 homolog, hAVO3, KIAA1999, Rapamycin-insensitive companion of mTOR
| Host / Isotype: Mouse / IgG1 | Class: Monoclonal |
| Reactivity: human, mouse, rat | Immunogen: CatNo: Ag28487 Product name: Recombinant human RICTOR protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 1-183 aa of BC029608 Sequence: MAAIGRGRSLKNLRVRGRNDSGEENVPLDLTREPSDNLREILQNVARLQGVSNMRKLGHLNNFTKLLCDIGHSEEKLGFHYEDIIICLRLALLNEAKEVRAAGLRALRYLIQDSSILQKVLKLKVDYLIARCIDIQQSNEVERTQALRLVRKMITVNASLFPSSVTNSLIAVGNDGLQERDRM Predict reactive species |
| Applications: WB, IF/ICC, ELISA | Observed Molecular Weight: 192 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC029608 |
| Conjugate: Unconjugated | Gene Symbol: RICTOR |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 253260 |
| Application: Western Blot (WB) | RRID: AB_2882204 |
| Dilution: WB : 1:1000-1:6000 | Conjugate: Unconjugated |
| Tested Reactivity: Human, Mouse, Rat | Form: Liquid |
| Host / Isotype: Mouse / IgG1 | Background Information: RICTOR, is a?key component of the mTOR complex 2 (mTORC2) and is required for phosphorylation of Akt at serine 473. RICTOR is the upstream kinase of several AGC kinase family members including AKT, SGK, S6K mutants and several PKC isoforms. Activation of RICTOR-mTORC2 modifies actin organization and promotes cell proliferation and survival. Rictor is overexpressed in several cancers leading to hyperactive mTORC2 and has been shown to play a causal role in glioma formation. Rictor expression has been demonstrated to be regulated transcriptionally and via protein degradation. |
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