KLF6 Monoclonal antibody proteintech 67297-1-Ig
$449.00
In stock
SKU
67297-1-Ig
BCD1, B-cell-derived protein 1, COPEB, Core promoter element-binding protein, CPBP
| Host / Isotype: Mouse / IgG1 | Class: Monoclonal |
| Reactivity: Human And More (1) | Immunogen: CatNo: Ag6859 Product name: Recombinant human KLF6 protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 6-283 aa of BC000311 Sequence: MCSIFQELQIVHETGYFSALPSLEEYWQQTCLELERYLQSEPCYVSASEIKFDSQEDLWTKIILAREKKEESELKISSSPPEDTLISPSFCYNLETNSLNSDVSSESSDSSEELSPTAKFTSDPIGEVLVSSGKLSSSVTSTPPSSPELSREPSQLWGCVPGELPSPGKVRSGTSGKPGDKGNGDASPDGRRRVHRCHFNGCRKVYTKSSHLKAHQRTHTGEKPYRCSWEGCEWRFARSDELTRHFRKHTGAKPFKCSHCDRCFSRSDHLALHMKRHL Predict reactive species |
| Applications: WB, ChIP, ELISA | Observed Molecular Weight: 32 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC000311 |
| Conjugate: Unconjugated | Gene Symbol: KLF6 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 1316 |
| Application: Western Blot (WB) | RRID: AB_2882561 |
| Dilution: WB : 1:1000-1:6000 | Conjugate: Unconjugated |
| Tested Reactivity: Human | Form: Liquid |
| Host / Isotype: Mouse / IgG1 | Background Information: KLF6(krupple-like factor 6) is a zinc finger transcription factor and tumor suppressor with biological activities and transcriptional targets in growing range. It is highly expressed in placenta followed by spleen, thymus, prostate, testis, small intestine and colon. One key target gene of KLF6 in endoglin, which is a homodimeric cell membrane glycoprotein and TGF-β auxiliary receptor, owns a pro-angiogenic role in endothelial cells and is also involved in malignant progression. Also KLF6 induces apoptosis in prostate cancer cells through upregulation of ATF3. KLF6 was normal detected as a 46kDa protein, which is larger than translation product(32kDa), because of post-translational modification including both phosphorylation and glycosylation. This antibody raise against the full length of KLF6 gene of human origin, and can recognize both of KLF6, included KLF6(~32kDa), p-KLF6(~35-46kDa). Otherwise, there may be a non-specific band(50kDa) showed in detection |
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