Cathepsin L Monoclonal antibody proteintech 66914-1-Ig
$449.00
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66914-1-Ig
CTSL1, 1A12G8, Cathepsin L heavy chain, Cathepsin L light chain, cathepsin L1
| Host / Isotype: Mouse / IgG2b | Class: Monoclonal |
| Reactivity: human | Immunogen: CatNo: Ag27951 Product name: Recombinant human Cathepsin L protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 1-333 aa of BC012612 Sequence: MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNVKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV Predict reactive species |
| Applications: WB, IHC, IF/ICC, ELISA | Observed Molecular Weight: 38 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC012612 |
| Conjugate: Unconjugated | Gene Symbol: Cathepsin L |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 1514 |
| Application: Western Blot (WB) | RRID: AB_2882241 |
| Dilution: WB : 1:1000-1:8000 | Conjugate: Unconjugated |
| Tested Reactivity: Human | Form: Liquid |
| Host / Isotype: Mouse / IgG2b | Background Information: CTSL1(Cathepsin L1) is also named as CTSL and MEP, belongs to the peptidase C1 family. It is a lysosomal proteinase whose expression is also up-regulated in the skeletal muscle during starvation(PMID:20088826). It plays an intracellular role in normal intestinal epithelial polarization and initiation of neoplasia(PMID:17622569). CTSL1 also improves cardiac function and inhibits cardiac hypertrophy, inflammation, and fibrosis through blocking AKT/GSK3B signaling(PMID:19096818). The full length protein is 38 kDa with a signal peptide, two propeptide and a glycosylation site. It has been detected the 36 kDa, 39 kDa, 29 kDa and 21 kDa in rat gastrocnemius muscle. These forms of cathepsin L could either be attributed to di?erences in glycosylation or to partial processing of the proenzyme. (PMID:11696001) |
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