IFIH1/MDA5 Monoclonal antibody proteintech 66770-1-Ig
$449.00
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66770-1-Ig
IFIH1, MDA5, 3D8B11, CADM-140 autoantigen, Clinically amyopathic dermatomyositis autoantigen 140 kDa
| Host / Isotype: Mouse / IgG1 | Class: Monoclonal |
| Reactivity: Human And More (3) | Immunogen: CatNo: Ag17448 Product name: Recombinant human IFIH1 protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 1-310 aa of BC111750 Sequence: MSNGYSTDENFRYLISCFRARVKMYIQVEPVLDYLTFLPAEVKEQIQRTVATSGNMQAVELLLSTLEKGVWHLGWTREFVEALRRTGSPLAARYMNPELTDLPSPSFENAHDEYLQLLNLLQPTLVDKLLVRDVLDKCMEEELLTIEDRNRIAAAENNGNESGVRELLKRIVQKENWFSAFLNVLRQTGNNELVQELTGSDCSESNAEIENLSQVDGPQVEEQLLSTTVQPNLEKEVWGMENNSSESSFADSSVVSESDTSLAEGSVSCLDESLGHNSNMGSDSGTMGSDSDEENVAARASPEPELQLRP Predict reactive species |
| Applications: WB, IHC, IF, FC (Intra), ELISA | Observed Molecular Weight: 1025 aa, 117 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC111750 |
| Conjugate: Unconjugated | Gene Symbol: IFIH1 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 64135 |
| Application: Western Blot (WB) | RRID: AB_2882116 |
| Dilution: WB : 1:5000-1:50000 | Conjugate: Unconjugated |
| Tested Reactivity: Human | Form: Liquid |
| Host / Isotype: Mouse / IgG1 | Background Information: IFIH1 (Interferon-induced helicase C domain-containing protein 1) is a putative RNA helicase that is upregulated in response to treatment with IFNB or IFNB and MEZ. It is also named as MDA5 and RH116. Ectopic expression of MDA5 in melanoma cells resulted in reduced colony formation, suggesting an interaction of the CARD and apoptotic signal molecules. Functional analysis indicated that MDA5 is an RNA-dependent ATPase. IFIH1 has an apparent molecular mass of 117-130 kDa, and always other bands (70 kDa and 90 kDa) can be detected as cleaved products (PMID: 17267501). |
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