Anti-Human CD107a / LAMP1 (H4A3) proteintech 65051-1-Ig
$68.00
In stock
SKU
65051-1-Ig
CD107a, LAMP1, CD107 antigen-like family member A, CD107a/LAMP1, H4A3
| Host / Isotype: Mouse / IgG1, kappa | Class: Monoclonal |
| Reactivity: Human And More (2) | Immunogen: Human adherent peripheral blood cells Predict reactive species |
| Applications: WB, IF/ICC, FC (Intra) | Observed Molecular Weight: 45 kDa |
| Formulation: PBS, Azide | GenBank Accession Number: BC006345 |
| Conjugate: Unconjugated | Gene Symbol: LAMP1 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 3916 |
| Application: Western Blot (WB) | RRID: ENSG00000185896 |
| Dilution: WB : 1:1000-1:8000 | Conjugate: AB_2881467 |
| Tested Reactivity: Human | Form: Unconjugated |
| Host / Isotype: Mouse / IgG1, kappa | Background Information: LAMP1 (CD107a) is a heavily glycosylated membrane protein enriched in the lysosomal membrane. LAMP1 is extensively glycosylated with asparagine-linked oligosaccharides which protect it from intracellular proteolysis (PMID: 10521503). Although LAMP1 is expressed largely in the endosome-lysosomal membrane of cells, it is also found on the plasma membrane (PMID: 16168398). Elevated LAMP1 expression at the cell surface has also been detected during platelet and granulocytic cell activation, as well as in some tumor cells (PMID: 29085473). LAMP1 functions to provide selectins with carbohydrate ligands. This protein has also been shown to be a marker of degranulation on lymphocytes such as CD8+ and NK cells and may also play a role in tumor cell differentiation and metastasis (PMID: 18835598; 29085473; 9426697). |
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