STUB1 Monoclonal antibody proteintech 68407-1-Ig
$449.00
In stock
SKU
68407-1-Ig
CHIP, 2E6B9, Antigen NY-CO-7, Carboxy terminus of Hsp70-interacting protein, CLL-associated antigen KW-8
| Host / Isotype: Mouse / IgG1 | Class: Antibody |
| Reactivity: human, rat | Immunogen: STIP1 homology and U-box containing protein 1 |
| Applications: WB, IF/ICC, ELISA | Observed Molecular Weight: 35 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: STUB1 |
| Conjugate: Unconjugated | Gene Symbol: 10273 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): AB_3085124 |
| Application: Western Blot (WB) | RRID: Unconjugated |
| Dilution: WB : 1:5000-1:50000 | Conjugate: Liquid |
| Tested Reactivity: Human, Rat | Form: Protein G purification |
| Host / Isotype: Monoclonal | Background Information: STUB1, also named as CHIP, SDCCAG7, UBOX1 and NY-CO-7, is a E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. STUB1/CHIP modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. It mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. STUB1/CHIP mediates polyubiquitination of CYP3A4.(PMID:10330192) CHIP/STUB1 strongly reduced keratin aggregates through increased degradation of mutant K14. (PMID:20151404) STUB1/CHIP regulates NAD(P)H:quinone oxidoreductase 1 (NQO1) accumulation in aged brain, a process impaired in certain Alzheimer patients.(PMID:21220432 ) This antibody is specific to STUB1. |
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