Collagen Type I Monoclonal antibody proteintech 67288-1-Ig
$449.00
In stock
SKU
67288-1-Ig
COL1A1, 1E9A7, Alpha 1 type I collagen, Alpha-1 type I collagen, COL I
| Host / Isotype: Mouse / IgG1 | Class: Monoclonal |
| Reactivity: Human, Pig And More (2) | Immunogen: Peptide Predict reactive species |
| Applications: WB, IHC, IF/ICC, IF-P, CoIP, ELISA | Observed Molecular Weight: 139 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: NM_000088 |
| Conjugate: Unconjugated | Gene Symbol: COL1A1 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 1277 |
| Application: Western Blot (WB) | RRID: AB_2882554 |
| Dilution: WB : 1:5000-1:50000 | Conjugate: Unconjugated |
| Tested Reactivity: Human, Pig | Form: Liquid |
| Host / Isotype: Mouse / IgG1 | Background Information: Type I collagen, the major structural component of connective tissues such as skin, tendon and bone, is the most abundant and widely expressed collagen in humans (PMID: 7620364; 8645190; 9016532). Type I collagen is a heterotrimer comprising one alpha 2(I) and two alpha 1(I) chains which are encoded by the unlinked loci COL1A2 and COL1A1 respectively. Mutations in COL1A1 are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. This antibody raised against a synthesized peptide corresponding to 1206-1218 aa of human pro-alpha 1 chain of type I collagen recognize collagen alpha-1(I) chain. The presence of unprocessed, intermediate, and mature chains of type I collagen was clearly detected only in static constructs. Indeed, in sponges cultured under perfusion the presence of type I collagen was mainly restricted to mature chains, suggesting that HACs were no longer actively producing type I collagen (PMID: 27584727). It is reported that the molecular weight is 200kDa(PMID: 28526934). |
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