ZCCHC11 Polyclonal antibody proteintech 18980-1-AP
$449.00
In stock
SKU
18980-1-AP
| Host / Isotype: Rabbit / IgG | Class: Polyclonal |
| Reactivity: human, mouse | Immunogen: Peptide Predict reactive species |
| Applications: WB, IF/ICC, IP, CoIP, ELISA | Observed Molecular Weight: 185 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: NM_015269 |
| Conjugate: Unconjugated | Gene Symbol: ZCCHC11 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 23318 |
| Application: Western Blot (WB) | RRID: AB_10598327 |
| Dilution: WB : 1:500-1:1000 | Conjugate: Unconjugated |
| Tested Reactivity: Human, Mouse | Form: Liquid |
| Host / Isotype: Rabbit / IgG | Background Information: ZCCHC11, also named as KIAA0191 and TUT4, is an uridylyltransferase that acts as a suppressor of microRNA (miRNA) biogenesis by specifically mediating the terminal uridylation of some miRNAs. ZCCHC11 catalyzes the 3' uridylation of precursor let-7 (pre-let-7), a miRNA precursor. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cells and is required for ES cells to maintain pluripotency. ZCCHC11 can't bind RNA by itself, recruited to pre-let-7 miRNAs via its interaction with LIN28 and LIN28B. Also catalyzes the 3' uridylation of miR-26A, a miRNA that represses IL6 transcript, leading to abrogate IL6 transcript repression and promote cytokine expression. ZCCHC11 may also suppress Toll-like receptor-induced NF-kappa-B activity via binding to T2BP.This antibody is specifical to the 185 kd ZCCHCC11 protein. |
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