HDAC5-specific Polyclonal antibody proteintech 16166-1-AP
$449.00
In stock
SKU
16166-1-AP
| Host / Isotype: Rabbit / IgG | Class: Polyclonal |
| Reactivity: Human, Mouse And More (1) | Immunogen: Peptide Predict reactive species |
| Applications: WB, IHC, IF/ICC, CoIP, ChIP, ELISA | Observed Molecular Weight: 122 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC051824 |
| Conjugate: Unconjugated | Gene Symbol: HDAC5 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 10014 |
| Application: Western Blot (WB) | RRID: AB_2116779 |
| Dilution: WB : 1:100-1:1000 | Conjugate: Unconjugated |
| Tested Reactivity: Human, Mouse | Form: Liquid |
| Host / Isotype: Rabbit / IgG | Background Information: Histone acetylation and deacetylation alternately expose and occlude DNA to transcription factors. At least 4 classes of HDAC were identified. HDAC5 is a class II HDAC. HDAC5 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3, and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. HDAC5 is involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, HDAC5 shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. This antibody only binds HDAC5. It does not cross-react with other HDACs. |
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