Phospho-P53 (Ser15) Polyclonal antibody proteintech 28961-1-AP
$449.00
In stock
SKU
28961-1-AP
TP53, P53, Tumour Protein p53, Tumor suppressor p53, tumor protein p53
| Host / Isotype: Rabbit / IgG | Class: Polyclonal |
| Reactivity: Human And More (1) | Immunogen: Peptide Predict reactive species |
| Applications: WB, IHC, IF/ICC, ELISA | Observed Molecular Weight: 44 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC003596 |
| Conjugate: Unconjugated | Gene Symbol: P53 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 7157 |
| Application: Western Blot (WB) | RRID: AB_2881236 |
| Dilution: WB : 1:1000-1:4000 | Conjugate: Unconjugated |
| Tested Reactivity: Human | Form: Liquid |
| Host / Isotype: Rabbit / IgG | Background Information: The p53 tumor suppressor protein plays a major role in cellular response to DNA damage and other genomic aberrations. Activation of p53 can lead to either cell cycle arrest and DNA repair or apoptosis . DNA damage induces phosphorylation of p53 at Ser15 and Ser20 and leads to a reduced interaction between p53 and its negative regulator, the oncoprotein MDM2. p53 can be phosphorylated by ATM, ATR, and DNA-PK at Ser15 and Ser37. Phosphorylation impairs the ability of MDM2 to bind p53, promoting both the accumulation and activation of p53 in response to DNA damage. |
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