CD117/c-Kit Polyclonal antibody proteintech 18696-1-AP
$449.00
In stock
SKU
18696-1-AP
CD117, KIT, Mast/stem cell growth factor receptor Kit, EC:2.7.10.1, c-Kit
| Host / Isotype: Rabbit / IgG | Class: Polyclonal |
| Reactivity: Human And More (4) | Immunogen: Peptide Predict reactive species |
| Applications: WB, IHC, IF/ICC, ELISA | Observed Molecular Weight: 110 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC071593 |
| Conjugate: Unconjugated | Gene Symbol: CD117 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 3815 |
| Application: Western Blot (WB) | RRID: AB_2249558 |
| Dilution: WB : 1:1000-1:4000 | Conjugate: Unconjugated |
| Tested Reactivity: Human | Form: Liquid |
| Host / Isotype: Rabbit / IgG | Background Information: CD117, also known as c-Kit and SCFR, is a transmembrane protein with tyrosine kinase activity encoded by the oncogene c-kit (PMID: 2448137). It is a member of the type III receptor tyrosine kinase family, which also includes CSF-1R, PDGFRβ, PDGFRα, and FLT3 (PMID: 29518044). CD117 is expressed on hematopoietic stem cells and progenitor cells, mast cells, and is also found in a wide range of non-haemopoietic cell types (including melanocytes, germ cells, astrocytes, renal tubules, breast glandular epithelial cells, sweat glands, and interstitial cells of Cajal) (PMID: 10582338; 23073628). CD117 plays an important role in early hemopoiesis. It is also involved in pigmentation, fertility, gut movement, and some aspects of the nervous system (PMID: 23073628). |
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