Phospho-ERK1/2 (Thr202/Tyr204) Polyclonal antibody proteintech 28733-1-AP
$449.00
In stock
SKU
28733-1-AP
ERK1/2 (Thr202/Tyr204), p ERK, p ERK1/2, p ERK1/2 (Thr202/Tyr204), p ERK1/2 Thr202/Tyr204
| Host / Isotype: Rabbit / IgG | Class: Polyclonal |
| Reactivity: Human, Mouse And More (6) | Immunogen: Peptide Predict reactive species |
| Applications: WB, IHC, IF, IP, ELISA | Observed Molecular Weight: 38-43 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: NM_002746 |
| Conjugate: Unconjugated | Gene Symbol: ERK1 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 5595 |
| Application: Western Blot (WB) | RRID: AB_2881202 |
| Dilution: WB : 1:1000-1:4000 | Conjugate: Unconjugated |
| Tested Reactivity: Human, Mouse | Form: Liquid |
| Host / Isotype: Rabbit / IgG | Background Information: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. MEK1 and MEK2 activate p44 and p42 through phosphorylation of activation loop residues Thr202/Tyr204 and Thr185/Tyr187, respectively. Several downstream targets of p44/42 have been identified, including p90RSK and the transcription factor Elk-1. This antibody simultaneously recognizes the phosphorylation of ERK1 at Thr202 and Tyr204, as well as the phosphorylation of ERK2 at Thr185 and Tyr187. |
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