IL-1 alpha Polyclonal antibody proteintech 16765-1-AP
$449.00
In stock
SKU
16765-1-AP
IL 1 alpha, IL1A, Hematopoietin-1, IL 1A, IL1 ALPHA
| Host / Isotype: Rabbit / IgG | Class: Polyclonal |
| Reactivity: Human And More (2) | Immunogen: CatNo: Ag10339 Product name: Recombinant human IL-1 alpha protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-271 aa of BC013142 Sequence: MAKVPDMFEDLKNCYSENEEDSSSIDHLSLNQKSFYHVSYGPLHEGCMDQSVSLSISETSKTSKLTFKESMVVVATNGKVLKKRRLSLSQSITDDDLEAIANDSEEEIIKPRSAPFSFLSNVKYNFMRIIKYEFILNDALNQSIIRANDQYLTAAALHNLDEAVKFDMGAYKSSKDDAKITVILRISKTQLYVTAQDEDQPVLLKEMPEIPKTITGSETNLLFFWETHGTKNYFTSVAHPNLFIATKQDYWVCLAGGPPSITDFQILENQA Predict reactive species |
| Applications: WB, IHC, IF, ELISA | Observed Molecular Weight: 271 aa, 31 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC013142 |
| Conjugate: Unconjugated | Gene Symbol: IL-1 alpha |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 3552 |
| Application: Western Blot (WB) | RRID: AB_10641044 |
| Dilution: WB : 1:500-1:2000 | Conjugate: Unconjugated |
| Tested Reactivity: Human | Form: Liquid |
| Host / Isotype: Rabbit / IgG | Background Information: Interleukin-1α (IL-1 alpha) is a protein that plays a crucial role in the regulation of a number of key cellular processes. IL-1 Alpha is a cytokine and a potent mediator of body's response to inflammation, microbial invasion, tissue injury and immunological response. In addition, recent studies suggest that IL-1 Alpha also has a role in wound healing, rheumatoid arthritis, Alzheimer's disease and tumor growth. IL-1 Alpha functions as an alarmin during the process of sterile inflammation. It serves as a signal from dying cells to potentiate the inflammatory response, increasing the expression of other secreted factors like IL-6 and IL-8. IL-1 Alpha was found to affect the cell cycle of osteosarcoma cell to reduce cell growth. IL-1 Alpha is initially translated as approximately 30-kD polypeptides that are processed to approximately 17.5-kD polypeptides prior to, or during, release from macrophages. |
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