AKT Polyclonal antibody proteintech 10176-2-AP
$449.00
In stock
SKU
10176-2-AP
AKT 1, AKT1, EC:2.7.11.1, PKB, PKB ALPHA
| Host / Isotype: Rabbit / IgG | Class: Polyclonal |
| Reactivity: Human, Mouse, Rat And More (7) | Immunogen: CatNo: Ag0213 Product name: Recombinant human AKT protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-224 aa of BC000479 Sequence: MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLC Predict reactive species |
| Applications: WB, IHC, IF-P, IF-Fro, IP, CoIP, ELISA | Observed Molecular Weight: 56 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC000479 |
| Conjugate: Unconjugated | Gene Symbol: AKT1 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 207 |
| Application: Western Blot (WB) | RRID: AB_2224574 |
| Dilution: WB : 1:2000-1:12000 | Conjugate: Unconjugated |
| Tested Reactivity: Human, Mouse, Rat | Form: Liquid |
| Host / Isotype: Rabbit / IgG | Background Information: The serine-threonine protein kinase AKT1 is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. |
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