IL-33 Polyclonal antibody proteintech 28035-1-AP
$449.00
In stock
SKU
28035-1-AP
Il33, Il 33, Il1f11, interleukin 33, NF HEV
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: mouse, rat | Immunogen: interleukin 33 |
| Applications: WB, IHC, ELISA | Observed Molecular Weight: 30-35 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: IL-33 |
| Conjugate: Unconjugated | Gene Symbol: 77125 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): AB_2881042 |
| Application: Western Blot (WB) | RRID: Unconjugated |
| Dilution: WB : 1:500-1:2000 | Conjugate: Liquid |
| Tested Reactivity: Mouse, Rat | Form: Antigen affinity purification |
| Host / Isotype: Polyclonal | Background Information: Interleukin-33 (IL-33) is a tissue-derived nuclear cytokine from the IL-1 family abundantly expressed in endothelial cells, epithelial cells and fibroblast-like cells, both during homeostasis and inflammation. IL-33 activates many immune cell types involved in type-2 immunity and allergic inflammation, including ILC2s, mast cells, Th2 cells, eosinophils, basophils, dendritic cells and alternatively activated macrophages (AAM). As a cytokine, IL-33 interacts with the receptors ST2 (also known as IL1RL1) and IL-1 Receptor Accessory Protein (IL1RAP), activating intracellular molecules in the NF-κB and MAP kinase signaling pathways that drive production of type 2 cytokines (e.g. IL-5 and IL-13) from polarized Th2 cells. IL-33 is also effective in reversing Alzheimer-like symptoms in APP/PS1 mice, by reversing the buildup and preventing the new formation of amyloid plaques. IL-33 is synthesized as a 30-34 kD full-length form and 20 kDa form mature form. |
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