TNF-alpha Polyclonal antibody proteintech 26405-1-AP
$449.00
In stock
SKU
26405-1-AP
TNF, TNF alpha, TNF-a, C-domain 1, C-domain 2
| Host / Isotype: Rabbit / IgG | Class: Polyclonal |
| Reactivity: Human And More (3) | Immunogen: CatNo: Ag24020 Product name: Recombinant human TNF-a protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 77-233 aa of BC028148 Sequence: VRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL Predict reactive species |
| Applications: WB, IHC, IF/ICC, ELISA | Observed Molecular Weight: 233 aa, 26 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC028148 |
| Conjugate: Unconjugated | Gene Symbol: TNF-alpha |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 7124 |
| Application: Western Blot (WB) | RRID: ENSG00000232810 |
| Dilution: WB : 1:500-1:2000 | Conjugate: AB_2918102 |
| Tested Reactivity: Human | Form: Unconjugated |
| Host / Isotype: Rabbit / IgG | Background Information: TNF, as also known as TNF-alpha, or cachectin, is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. It is expressed as a 26 kDa membrane bound protein and is then cleaved by TNF-alpha converting enzyme (TACE) to release the soluble 17 kDa monomer, which forms homotrimers in circulation. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, ins resistance, and cancer. |
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