Raptor Polyclonal antibody proteintech 20984-1-AP
$449.00
In stock
SKU
20984-1-AP
KIAA1303, p150 target of rapamycin, Regulatory-associated protein of mTOR, RPTOR, TOR
| Host / Isotype: Rabbit / IgG | Class: Polyclonal |
| Reactivity: Human, Mouse And More (2) | Immunogen: Peptide Predict reactive species |
| Applications: WB, IHC, IF/ICC, IP, ELISA, PLA | Observed Molecular Weight: 149 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: NM_020761 |
| Conjugate: Unconjugated | Gene Symbol: Raptor |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 57521 |
| Application: Western Blot (WB) | RRID: AB_11182390 |
| Dilution: WB : 1:2000-1:12000 | Conjugate: Unconjugated |
| Tested Reactivity: Human, Mouse | Form: Liquid |
| Host / Isotype: Rabbit / IgG | Background Information: RPTOR, also named as KIAA1303 and RAPTOR Belongs to the WD repeat RAPTOR family. It is involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals; functions as a scaffold for recruiting mTORC1 substrates. mTORC1 is activated in response to growth factors or amino-acids. Amino-acid-signaling to mTORC1 is mediated by Rag GTPases, which cause amino-acid-induced relocalization of mTOR within the endomembrane system. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. The antibody is specific to RPTOR. |
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