Phospho-p70(S6K) (Thr389)/p85(S6K) (Thr412) Polyclonal antibody proteintech 28735-1-AP
$449.00
In stock
SKU
28735-1-AP
p p70(S6K), p p70(S6K) (Thr389), p p70(S6K) Thr389, p70 S6 Kinase (Thr389), p70(S6K) (Thr389)
| Host / Isotype: Rabbit / IgG | Class: Polyclonal |
| Reactivity: Human And More (4) | Immunogen: Peptide Predict reactive species |
| Applications: WB, IHC, ELISA | Observed Molecular Weight: 65-85 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: p70 S6K |
| Conjugate: Unconjugated | Gene Symbol: 6198 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): AB_2918197 |
| Application: Western Blot (WB) | RRID: Unconjugated |
| Dilution: WB : 1:1000-1:8000 | Conjugate: Liquid |
| Tested Reactivity: Human | Form: Antigen affinity purification |
| Host / Isotype: Rabbit / IgG | Background Information: The Rps6kb1 gene encodes the 70?kDa ribosomal protein S6 kinase (p70S6K), which is a serine/threonine kinase regulated by phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) pathway. P70(S6K) plays a crucial role in controlling cell cycle, growth and survival. The PI3K/mTOR signalling pathway is one of the major mechanisms for controlling cell survival, proliferation and metabolism and is the central regulator of translation of some components of protein synthesis system. Due to alternative translation two isoform S6K1 proteins are known to exist in mammalian cells: p85(S6K) and p70(S6K), which is identical to p85(S6K) but lacks its first 23 amino acids. In addition, mammalian cells express a second S6K1 isoform spanning 316 amino acids (p31 S6K1). mTOR is know to phosphorylate and thereby activate p70(S6K) at Thr389 and p85(S6K) at Thr412. (PMID:?25100792, PMID:?24970012, PMID:?21602892) |
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