MEF2C Polyclonal antibody proteintech 10056-1-AP
$449.00
In stock
SKU
10056-1-AP
myocyte enhancer factor 2C, Myocyte-specific enhancer factor 2C
| Host / Isotype: Rabbit / IgG | Class: Polyclonal |
| Reactivity: Human, Mouse And More (4) | Immunogen: CatNo: Ag0020 Product name: Recombinant human MEF2C protein Source: e coli.-derived, Unknow Tag: N/A Domain: MEF2C of BC156603 Sequence: Predict reactive species |
| Applications: WB, IHC, IF/ICC, FC (Intra), IP, chIP, ELISA | Observed Molecular Weight: 51 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC156603 |
| Conjugate: Unconjugated | Gene Symbol: MEF2C |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 4208 |
| Application: Western Blot (WB) | RRID: AB_513447 |
| Dilution: WB : 1:500-1:1000 | Conjugate: Unconjugated |
| Tested Reactivity: Human, Mouse | Form: Liquid |
| Host / Isotype: Rabbit / IgG | Background Information: MEF2C belongs to the MEF2 family. It is a transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. MEF2C controls cardiac morphogenesis and myogenesis, and is also involved in vascular development[PMID: 20221419]. It plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission[PMID:18599438]. It is crucial for normal neuronal development, distribution, and electrical activity in the neocortex and is necessary for proper development of megakaryocytes and platelets and for bone marrow B lymphopoiesis[PMID: 21666133]. This protein is required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B cells. It may also be involved in neurogenesis and in the development of cortical architecture. MEF2C exists some isoforms with MV 50-52 kDa, 47 kDa, and 45 kDa, but modified MEF2C is about 55-66 kDa. |
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