FAM134B Polyclonal antibody proteintech 21537-1-AP
$449.00
In stock
SKU
21537-1-AP
JK1, Reticulophagy receptor 1, Reticulophagy regulator 1, RETREG1
| Host / Isotype: Rabbit / IgG | Class: Polyclonal |
| Reactivity: Human, Mouse, Rat And More (2) | Immunogen: CatNo: Ag16176 Product name: Recombinant human FAM134B protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 282-455 aa of BC030517 Sequence: ELDFSALCPKISLTVAAKELSVSDTDVSEVSWTDNGTFNLSEGYTPQTDTSDDLDRPSEEVFSRDLSDFPSLENGMGTNDEDELSLGLPTELKRKKEQLDSGHRPSKETQSAAGLTLPLNSDQTFHLMSNLAGDVITAAVTAAIKDQLEGVQQALSQAAPIPEEDTDTEEGDDF Predict reactive species |
| Applications: WB, IHC, IF, IP, ELISA | Observed Molecular Weight: 497 aa, 55 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC030517 |
| Conjugate: Unconjugated | Gene Symbol: FAM134B |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 54463 |
| Application: Western Blot (WB) | RRID: AB_2878879 |
| Dilution: WB : 1:2000-1:16000 | Conjugate: Unconjugated |
| Tested Reactivity: Human, Mouse, Rat | Form: Liquid |
| Host / Isotype: Rabbit / IgG | Background Information: FAM134B, also known as the reticulophagy regulator 1 (RETREG1) or JK-1, is a member of the family with sequence similarity 134. FAM134B is an important ER-phagy receptor. FAM134B regulates the size and shape of the ER and participates in some ER-phagy-related processes(PMID: 33199694). FAM134B inhibition contributes to impair proteostasis in the ER due to the accumulation of misfolded or aggregated proteins, which in turn leads to compromised neuronal survival and progressive neuronal degenerative diseases. In addition, FAM134B mutations are common in patients with colorectal adenocarcinoma, and oesophageal squamous cell carcinoma(PMID: 29226326). |
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