PYCR1 Polyclonal antibody proteintech 13108-1-AP
$449.00
In stock
SKU
13108-1-AP
EC:1.5.1.2, P5C, P5C reductase 1, P5CR, P5CR 1
| Host / Isotype: Rabbit / IgG | Class: Polyclonal |
| Reactivity: Human, Mouse, Rat And More (1) | Immunogen: CatNo: Ag3764 Product name: Recombinant human PYCR1 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-171 aa of BC022244 Sequence: MEQLLSSVGFCTEVEEDLIDAVTGLSGSGPAYAFTALDALADGGVKMGLPRRLAVRLGAQALLGAAKMLLHSEQHPGQLKDNVSSPGGATIHALHVLESGGFRSLLINAVEASCIRTRELQSMADQEQVSPAAIKKTILDKVKLDSPAGTALSPSGHTKLLPRSLAPAGKD Predict reactive species |
| Applications: WB, IHC, IF/ICC, IP, CoIP, ELISA | Observed Molecular Weight: 319 aa, 33.8 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC022244 |
| Conjugate: Unconjugated | Gene Symbol: PYCR1 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 5831 |
| Application: Western Blot (WB) | RRID: AB_2174878 |
| Dilution: WB : 1:1000-1:4000 | Conjugate: Unconjugated |
| Tested Reactivity: Human, Mouse, Rat | Form: Liquid |
| Host / Isotype: Rabbit / IgG | Background Information: PYCR1,also named as P5CR1, belongs to the pyrroline-5-carboxylate reductase family. It is a housekeeping enzyme that catalyzes the last step in proline biosynthesis. PYCR1 can utilize both NAD and NADP, but has higher affinity for NAD. It is involved in the cellular response to oxidative stress. Mutation in PYCR1 will cause ARCL type II(ARCL2B ). Some mutation will cause DeBarsy syndrome (DBS) which is characterized by progeroid features, ophthalmological abnormalities, intrauterine growth retardation, and cutis laxa. The MW of PYCR1 is about 33-35 kDa. PYCR1 has 3 isoforms produced by alternative splicing. This antibody may have cross reaction to PYCR2 due to the high homology. |
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