Cullin 5 Polyclonal antibody proteintech 31183-1-AP
$449.00
In stock
SKU
31183-1-AP
CUL5, CUL 5, CUL-5, Cullin-5, VACM 1
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human, mouse, rat | Immunogen: cullin 5 |
| Applications: WB, IHC, ELISA | Observed Molecular Weight: 80 kDa, 90 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: Cullin 5 |
| Conjugate: Unconjugated | Gene Symbol: 8065 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): AB_3669887 |
| Application: Western Blot (WB) | RRID: Unconjugated |
| Dilution: WB : 1:1000-1:10000 | Conjugate: Liquid |
| Tested Reactivity: Human, Mouse, Rat | Form: Antigen affinity Purification |
| Host / Isotype: Polyclonal | Background Information: The cullin family proteins are scaffold proteins for the RING finger type E3 ligases, participating in the proteolysis through the ubiquitin-proteasome pathway. In humans, there are eight members of cullins, including CUL1, 2, 3, 4A, 4B, 5, 7, and CUL9 with an evolutionarily conserved cullin homology domain at the C-terminus, responsible for their interaction with the RING protein, assembling 8 cullin-based RING dependent E3 ubiquitin ligases to target thousands of substrates for ubiquitination and degradation (PMID: 32334051). Cullin 5 is the key scaffolding protein of Cullin RING ligase-5 (CRL-5). Cullin 5 plays positive roles in regulating cell growth, proliferation and physiological and other processes in the human body (PMID: 32194910). Cullin 5 has been detected in the form of double bands in the results of Western blot, which might be caused by neddylation (PMID: 36449095; 31294695). |
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