PTCH2 Polyclonal antibody proteintech 55091-1-AP
$449.00
In stock
SKU
55091-1-AP
UNQ560/PRO1121/PRO57079, PTC2, Protein patched homolog 2, patched homolog 2 (Drosophila), Patched 2
| Host / Isotype: Rabbit / IgG | Class: Polyclonal |
| Reactivity: human, mouse, rat | Immunogen: Peptide Predict reactive species |
| Applications: WB, ELISA | Observed Molecular Weight: 131 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: NM_003738 |
| Conjugate: Unconjugated | Gene Symbol: PTCH2 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 8643 |
| Application: Western Blot (WB) | RRID: AB_10858392 |
| Dilution: WB : 1:500-1:1000 | Conjugate: Unconjugated |
| Tested Reactivity: Human, Mouse, Rat | Form: Liquid |
| Host / Isotype: Rabbit / IgG | Background Information: PTCH1 (patched homolog 1) and PTCH2 are twelve-pass transmembrane proteins that act receptors of Hedgehog signaling pathway (PMID: 8906794; 9811851). Signals of Hedgehog family proteins (SHH, IHH and DHH in humans) are transduced through Patched family receptors (PTCH1 and PTCH2) and Smoothened (SMO) to GLI family transcription factors. Hedgehog pathway plays a critical role in embryonic development and tissue homeostasis, and its dysregulation has been implicated in many human diseases including congenital disorder and cancer (PMID: 23719536; 23532857). PTCH2 may function as a tumor suppressor in the Hedgehog signaling pathway. Alterations in PTCH2 gene have been associated with nevoid basal cell carcinoma syndrome, basal cell carcinoma, medulloblastoma, and susceptibility to congenital macrostomia. This antibody is specific to PTCH2. |
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