PUMA Polyclonal antibody proteintech 55120-1-AP
$449.00
In stock
SKU
55120-1-AP
BBC3, BBC 3, Bcl-2-binding component 3, isoforms 1/2, JFY 1, JFY1
| Host / Isotype: Rabbit / IgG | Class: Polyclonal |
| Reactivity: Human, Mouse, Rat And More (1) | Immunogen: Peptide Predict reactive species |
| Applications: WB, IHC, IP, ELISA | Observed Molecular Weight: 21 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: NM_014417 |
| Conjugate: Unconjugated | Gene Symbol: PUMA |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 27113 |
| Application: Western Blot (WB) | RRID: AB_10859944 |
| Dilution: WB : 1:500-1:3000 | Conjugate: Unconjugated |
| Tested Reactivity: Human, Mouse, Rat | Form: Liquid |
| Host / Isotype: Rabbit / IgG | Background Information: PUMA, also named as JFY-1 and BBC3, belongs to the Bcl-2 family. It is a critical mediator of p53-dependent and -independent apoptosis induced by a wide variety of stimuli. It serves as a proximal signaling molecule whose expression is regulated by transcription factors in response to these stimuli. PUMA transduces death signals primarily to the mitochondria, where it acts indirectly on the Bcl-2 family members Bax and/or Bak by relieving the inhibition imposed by antiapoptotic members. It directly binds and antagonizes all known antiapoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. PUMA ablation or inhibition leads to apoptosis deficiency underlying increased risks for cancer development and therapeutic resistance. It is a general sensor of cell death stimuli and a promising drug target for cancer therapy and tissue damage. It is essential mediator of p53-dependent and p53-independent apoptosis (PMID: 19641508). Catalog #55120-1-AP can recognize PUMA alpha 21-24 kDa and PUMA beta 15-18 kDa. |
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