TET2 Polyclonal antibody proteintech 21207-1-AP
$449.00
In stock
SKU
21207-1-AP
EC:1.14.11.80, KIAA1546, Methylcytosine dioxygenase TET2, Nbla00191
| Host / Isotype: Rabbit / IgG | Class: Polyclonal |
| Reactivity: Human, Mouse And More (2) | Immunogen: CatNo: Ag15583 Product name: Recombinant human TET2 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-350 aa of BC150180 Sequence: MEQDRTNHVEGNRLSPFLIPSPPICQTERLATKLQNGSPLPERAHPEVNGDTKWHSFKSYYGIPCMKGSQNSRVSPDFTQESRGYSKCLQNGGIKRTVSEPSLSGLLQIKKLKQDQKANGERRNFGVSQERNPGESSQPNVSDLSDKKESVSSVAQENAVKDFTSFSTHNCSGPENPELQILNEQEGKSANYHDKNIVLLKNKAVLMPNGATVSASSVEHTHGELLEKTLSQYYPDCVSIAVQKTTSHINAINSQATNELSCEITHPSHTSGQINSAQTSNSELPPKPAAVVSEACDADDADNASKLAAMLNTCSFQKPEQLQQQKSVFEICPSPAENNIQGTTKLASGE Predict reactive species |
| Applications: WB, IHC, IF/ICC, FC (Intra), IP, CoIP, ChIP, RIP, ELISA | Observed Molecular Weight: 2002 aa, 224 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC150180 |
| Conjugate: Unconjugated | Gene Symbol: TET2 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 54790 |
| Application: Western Blot (WB) | RRID: AB_10734584 |
| Dilution: WB : 1:500-1:2000 | Conjugate: Unconjugated |
| Tested Reactivity: Human, Mouse | Form: Liquid |
| Host / Isotype: Rabbit / IgG | Background Information: TET2 is an enzyme which converts 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC) in DNA and is important for normal myelopoiesis. TET2 mutations are frequently observed in myeloid malignancies, including myeloproliferative neoplasms. TET2 is broadly expressed in a variety of tissues. In healthy tissues, TET2 expression was shown to be elevated in hematopoietic cells with highest expression in granulocytes. Three isoforms of TET2 exists due to the alternative splicing. 220-250 kDa bands represent the full-length isoform; 130-133 kDa bands represent the nuclear isoforms of TET2. (PMID: 24615693) This antibody recognizes all three isoforms of TET2. |
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