ZEB2 Polyclonal antibody proteintech 14026-1-AP
$449.00
In stock
SKU
14026-1-AP
KIAA0569, SIP 1, SIP1, Smad interacting protein 1, SMADIP1, ZEB2, ZFHX1B, ZFX1B
| Host / Isotype: Rabbit / IgG | Class: Polyclonal |
| Reactivity: Human And More (4) | Immunogen: CatNo: Ag5171 Product name: Recombinant human ZEB2 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-128 aa of BC060819 Sequence: MKQPIMADGPRCKRRKQANPRRKNVVNYDNVVDTGSETDEEDKLHIAEDDGIANPLDQETSPASVPNHESSPHVSQALLPREEEEDEIREGGVEHPWHNNEILQASVDGPGKCLKSLDLFLYHLHIFN Predict reactive species |
| Applications: WB, IHC, IF, CoIP, ChIP, RIP, ELISA | Observed Molecular Weight: 136 kDa |
| Formulation: PBS, Azide, Glycerol | GenBank Accession Number: BC060819 |
| Conjugate: Unconjugated | Gene Symbol: ZEB2 |
| Tested Applications: Positive WB detected in | Gene ID (NCBI): 9839 |
| Application: Western Blot (WB) | RRID: AB_2878001 |
| Dilution: WB : 1:2000-1:12000 | Conjugate: Unconjugated |
| Tested Reactivity: Human | Form: Liquid |
| Host / Isotype: Rabbit / IgG | Background Information: Zinc finger E-box-binding homeobox (ZEB2) is a key transcription factor that acts as a multifunctional regulator during nervous system development. ZEB2 contains two zinc finger domains and a homeodomain-like sequence and interacts with the TGF-? superfamily signaling regulators, Smads, to regulate the expression of their downstream genes.?ZEB2?is expressed in the developing neural tube, as well as in neural crest cells, the hippocampus and the cerebral cortex.?ZEB2 has previously been implicated in EMT, cell-cycle progression, apoptosis and senescence. ZEB2 was overexpressed in bladder, ovarian, stomach, pancreatic and squamous cell carcinoma, in the intestinal subtype of stomach cancers, and at the invasive front of CRC where EMT is most prominen. ZEB2 also mediates cell-fate decision in neuronal, T cells and hematopoietic stem cells. The calculated molecular weight of ZEB2 is 136 kDa, but we find the 95 kDa band in some publication(PMID: 27659015 ) |
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