Anti-Human MICA/MICB (6D4) Mouse IgG2a Recombinant Antibody proteintech 65589-1-MR
$71.00
In stock
SKU
65589-1-MR
MICB, MICA, 6D4, MIC A, MIC-A
| Host / Isotype: Mouse / IgG2a | Class: Antibody |
| Reactivity: human | Immunogen: MHC class I polypeptide-related sequence A |
| Applications: FC | Observed Molecular Weight: BC016929 |
| Formulation: PBS, Azide | GenBank Accession Number: 100507436 |
| Conjugate: Unconjugated | Gene Symbol: AB_3670339 |
| Tested Applications: Positive FC detected in | Gene ID (NCBI): Unconjugated |
| Application: Flow Cytometry (FC) | RRID: Liquid |
| Dilution: FC : 0.2 ug per 10^6 cells in 100 μl suspension | Conjugate: Protein A purification |
| Tested Reactivity: Human | Form: Q29983 |
| Host / Isotype: Recombinant | Background Information: Human MHC class I chain-related genes located within the HLA class I region of chromosome 6 encode MHC class I chain-related A and B (MICA and MICB) (PMID: 11429322). MICA and MICB are stress-inducible surface molecules that are not associated with β2-microglobulin and do not present peptides (PMID: 9497295). They are expressed in intestinal epithelium and many epithelial tumors (PMID: 10359807). MICA and MICB are ligands for NKG2D which is an activating receptor that is expressed on most natural killer (NK) cells, CD8 αβ T cells, and γδ T cells (PMID: 10426993; 11491531). The monoclonal antibody 6D4 recognizes MICA and MICB. |
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