Anti-Human LAIR1 Rabbit Recombinant Antibody proteintech 98326-1-RR
$115.00
In stock
SKU
98326-1-RR
Leukocyte-associated immunoglobulin-like receptor 1, LAIR-1, LAIR 1, hLAIR1, CD305
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human | Immunogen: leukocyte-associated immunoglobulin-like receptor 1 |
| Applications: FC | Observed Molecular Weight: BC027899 |
| Formulation: PBS, Azide | GenBank Accession Number: 3903 |
| Conjugate: Unconjugated | Gene Symbol: Unconjugated |
| Tested Applications: Positive FC detected in | Gene ID (NCBI): Liquid |
| Application: Flow Cytometry (FC) | RRID: Protein A purification |
| Dilution: FC : 0.13 ug per 10^6 cells in 100 μl suspension | Conjugate: Q6GTX8 |
| Tested Reactivity: Human | Form: PBS with 0.09% sodium azide, pH 7.3. |
| Host / Isotype: Recombinant | Background Information: Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) is a transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs (PMID: 9285412). LAIR1 is expressed on the majority of human PBMCs, including NK, T, B, monocytes, and dendritic cells, as well as the majority of thymocytes (PMID: 10229813). It functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of NK cells, B cells and T cells. LAIR1 is a collagen receptor (PMID: 16754721). Tumor-expressed collagens can modulate immune cell function through the inhibitory collagen receptor LAIR1 (PMID: 21955987). |
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