Anti-Human LAG-3/CD223 Rabbit Recombinant Antibody proteintech 98435-3-RR
$173.00
In stock
SKU
98435-3-RR
CD223, LAG3, FDC, LAG 3, LAG-3
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human | Immunogen: lymphocyte-activation gene 3 |
| Applications: IHC, FC | Observed Molecular Weight: NM_002286 |
| Formulation: PBS, Azide | GenBank Accession Number: 3902 |
| Conjugate: Unconjugated | Gene Symbol: Unconjugated |
| Tested Applications: Positive IHC detected in | Gene ID (NCBI): Liquid |
| Application: Immunohistochemistry (IHC) | RRID: Protein A purification |
| Dilution: IHC : 1:500-1:2000 | Conjugate: P18627 |
| Tested Reactivity: Human | Form: PBS with 0.09% sodium azide, pH 7.3. |
| Host / Isotype: Recombinant | Background Information: LAG-3, also known as CD223, is an immune checkpoint molecule that regulates both T-cell activation and homeostasis. LAG-3 is expressed on activated T cells, NK cells, regulatory T cells, and plasmacytoid dendritic cells. It is a CD4-related molecule that binds MHC class II. LAG-3 plays an important role in modulating T cell expansion and function, and blockade of LAG-3 with monoclonal antibodies can augment T cell function. (PMID: 15634887; 21086108; 28783703) |
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