Anti-Human KIR2DL3/CD158b2 Rabbit Recombinant Antibody proteintech 98373-3-RR
$67.00
In stock
SKU
98373-3-RR
KIR2DL3, Killer cell immunoglobulin-like receptor 2DL3, GL183, CD158B2, CD158b
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human | Immunogen: killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3 |
| Applications: FC | Observed Molecular Weight: NM_015868.2 |
| Formulation: PBS, Azide | GenBank Accession Number: 3804 |
| Conjugate: Unconjugated | Gene Symbol: Unconjugated |
| Tested Applications: Positive FC detected in | Gene ID (NCBI): Liquid |
| Application: Flow Cytometry (FC) | RRID: Protein A purfication |
| Dilution: FC : 0.25 ug per 10^6 cells in 100 μl suspension | Conjugate: P43628-1 |
| Tested Reactivity: Human | Form: PBS with 0.09% sodium azide, pH 7.3. |
| Host / Isotype: Recombinant | Background Information: Killer cell immunoglobulin-like receptors (KIRs) are a diverse family of inhibitory and activating receptors expressed on NK cells and a subset of T cells (PMID: 11861603). These polymorphic receptors interact with specific motifs on HLA class I molecules, modulate NK cytolytic activity and are encoded by genes located on chromosome 19q13.4 (PMID: 17069649). KIR2DL3, also known as CD158B2 or NKAT2, is an inhibitory receptor that is specific for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7) (PMID: 10196125). It is a 341-amino acid transmembrane glycoprotein consisting of an extracellular region containing two C2-type Ig-like domains, a 19-amino acid hydrophobic transmembrane region, and a long cytoplasmic tail with two immunoreceptor tyrosine-based inhibitory motifs (ITIMs). KIR2DL3 inhibits the cytolytic activity of NK cells thus preventing cell lysis (PMID: 7724594). |
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