Anti-Human gp130/IL6ST Rabbit Recombinant Antibody proteintech 98121-2-RR
$74.00
In stock
SKU
98121-2-RR
IL6ST, 242292C9, CD130, Glycoprotein 130, GP130
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human | Immunogen: interleukin 6 signal transducer (gp130, oncostatin M receptor) |
| Applications: FC | Observed Molecular Weight: NM_002184.3 |
| Formulation: PBS, Azide | GenBank Accession Number: 3572 |
| Conjugate: Unconjugated | Gene Symbol: Unconjugated |
| Tested Applications: Positive FC detected in | Gene ID (NCBI): Liquid |
| Application: Flow Cytometry (FC) | RRID: Protein A purfication |
| Dilution: FC : 0.25 ug per 10^6 cells in a 100 ?l suspension | Conjugate: P40189-1 |
| Tested Reactivity: Human | Form: PBS with 0.09% sodium azide, pH 7.3. |
| Host / Isotype: Recombinant | Background Information: Glycoprotein 130 (gp130, also known as IL6ST, CD130 or IL6-beta) is a ubiquitously expressed, signal-transducing receptor that serves as the signal transduction unit for IL-6 family of cytokines, including IL-6, IL-11, IL-27, leukemia inhibitory factor (LIF), OSM, ciliary neurotrophic factor (CNTF), cardiotrophin 1 (CT-1), and cardiotrophin-like cytokine (CLC) (PMID: 9143707; 20610800). These cytokines signal through the gp130/Jak/STAT pathway (PMID: 9716487). Binding of IL-6 to IL-6R induces gp130 homodimerization and formation of a high-affinity receptor complex, which activates Jaks. That causes phosphorylation of gp130 tyrosine residues which in turn activates STAT3. gp130 is a type I transmembrane protein, and can also exist as a soluble form (sgp130). sgp130 binds to sIL-6R/IL-6 complexes and prevents their interactions with membrane-anchored gp130 on target cells (PMID: 9815830). |
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