Anti-Human E-cadherin Rabbit Recombinant Antibody proteintech 98123-1-RR
$148.00
In stock
SKU
98123-1-RR
241098F7, Arc 1, Cadherin 1, Cadherin-1, CAM 120/80
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human | Immunogen: cadherin 1, type 1, E-cadherin (epithelial) |
| Applications: FC | Observed Molecular Weight: NM_004360.5 |
| Formulation: PBS, Azide | GenBank Accession Number: 999 |
| Conjugate: Unconjugated | Gene Symbol: AB_3672270 |
| Tested Applications: Positive FC detected in | Gene ID (NCBI): Unconjugated |
| Application: Flow Cytometry (FC) | RRID: Liquid |
| Dilution: FC : 0.25 ug per 10^6 cells in 100 μl suspension | Conjugate: Protein A purfication |
| Tested Reactivity: Human | Form: P12830-1 |
| Host / Isotype: Recombinant | Background Information: Cadherins are a family of transmembrane glycoproteins that mediate calcium-dependent cell-cell adhesion and play an important role in the maintenance of normal tissue architecture. E-cadherin (epithelial cadherin), also known as CD324, CDH1 (cadherin 1) or CAM 120/80, is a classical member of the cadherin superfamily which also include N-, P-, R-, and B-cadherins. E-cadherin is expressed on the cell surface in most epithelial tissues. The extracellular region of E-cadherin establishes calcium-dependent homophilic trans binding, providing specific interaction with adjacent cells, while the cytoplasmic domain is connected to the actin cytoskeleton through the interaction with p120-, α-, β-, and γ-catenin (plakoglobin). E-cadherin is important in the maintenance of the epithelial integrity, and is involved in mechanisms regulating proliferation, differentiation, and survival of epithelial cell. E-cadherin may also play a role in tumorigenesis. It is considered to be an invasion suppressor protein and its loss is an indicator of high tumor aggressiveness. |
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