Anti-Human CXCL4/PF4 Rabbit Recombinant Antibody proteintech 98410-3-RR
$179.00
In stock
SKU
98410-3-RR
CXCL4, PF4, SCYB4, C X C motif chemokine 4, C-X-C motif chemokine 4
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human | Immunogen: platelet factor 4 |
| Applications: FC (Intra) | Observed Molecular Weight: NM_002619.4 |
| Formulation: PBS, Azide | GenBank Accession Number: 5196 |
| Conjugate: Unconjugated | Gene Symbol: Unconjugated |
| Tested Applications: Positive FC (Intra) detected in | Gene ID (NCBI): Liquid |
| Application: Flow Cytometry (FC) (INTRA) | RRID: Protein A purification |
| Dilution: FC (INTRA) : 0.25 ug per 10^6 cells in a 100 ?l suspension | Conjugate: P02776 |
| Tested Reactivity: Human | Form: PBS with 0.09% sodium azide, pH 7.3. |
| Host / Isotype: Recombinant | Background Information: CXCL4, also known as platelet factor 4 (PF-4), is the oldest member of the chemokine family. CXCL4 is a chemokine produced by activated platelets and immune cells involved in pathological conditions such as cancer, infections and inflammatory diseases like systemic sclerosis (SSc), rheumatoid arthritis (RA) and psoriatic arthritis (PsA), among others. CXCL4 is present in the α-granules of platelets in amounts that constitute up to 2% platelet protein mass. CXCL4 plays a determinant role in distinct physiological processes such as in hematopoiesis, angiogenesis, coagulation and modulation of immune responses. For instance, CXCL4 can prevent monocyte apoptosis and promote cell survival, induces the production of TNF and reactive oxygen species (ROS) and promotes monocyte differentiation into a unique macrophage-like phenotype. |
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