Anti-Human CXCL10/IP-10 Rabbit Recombinant Antibody proteintech 98265-4-RR
$77.00
In stock
SKU
98265-4-RR
CXCL10, CXCL10/IP10, IP10, 10 kDa interferon gamma-induced protein, C X C motif chemokine 10
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human | Immunogen: chemokine (C-X-C motif) ligand 10 |
| Applications: FC (Intra) | Observed Molecular Weight: BC010954 |
| Formulation: PBS, Azide | GenBank Accession Number: 3627 |
| Conjugate: Unconjugated | Gene Symbol: Unconjugated |
| Tested Applications: Positive FC (Intra) detected in | Gene ID (NCBI): Liquid |
| Application: Flow Cytometry (FC) (INTRA) | RRID: Protein A purification |
| Dilution: FC (INTRA) : 0.25 ug per 10^6 cells in a 100 ?l suspension | Conjugate: P02778 |
| Tested Reactivity: Human | Form: PBS with 0.09% sodium azide, pH 7.3. |
| Host / Isotype: Recombinant | Background Information: CXCL10 (also known as IP-10) is a member of the CXC chemokine family which binds to the CXCR3 receptor to exert its biological effects. CXCL10 is a 12-kDa protein and constitutes two internal disulfide cross bridges. The predicted signal peptidase cleavage generates a 10-kDa secreted polypeptide with four conserved cysteine residues in the N-terminal. The CXCL10 gene localizes on chromosome 4 at band q21, a locus associated with an acute monocytic/B-lymphocyte lineage leukemia exhibiting translocation of t (4; 11) (q21; q23). CXCL10 mediates leukocyte trafficking, adaptive immunity, inflammation, haematopoiesis and angiogenesis. Under proinflammatory conditions CXCL10 is secreted from a variety of cells, such as leukocytes, activated neutrophils, eosinophils, monocytes, epithelial cells, endothelial cells, stromal cells (fibroblasts) and keratinocytes in response to IFN-γ. |
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