Anti-Human CD98/SLC3A2 Rabbit Recombinant Antibody proteintech 98190-1-RR
$67.00
In stock
SKU
98190-1-RR
CD98, SLC3A2, MDU1, Amino acid transporter heavy chain SLC3A2, 4F2 cell-surface antigen heavy chain
| Host / Isotype: Rabbit / IgG | Class: Antibody |
| Reactivity: human | Immunogen: solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 |
| Applications: FC | Observed Molecular Weight: NM_002394.5 |
| Formulation: PBS, Azide | GenBank Accession Number: 6520 |
| Conjugate: Unconjugated | Gene Symbol: Unconjugated |
| Tested Applications: Positive FC detected in | Gene ID (NCBI): Liquid |
| Application: Flow Cytometry (FC) | RRID: Protein A purfication |
| Dilution: FC : 0.25 ug per 10^6 cells in 100 μl suspension | Conjugate: P08195-1 |
| Tested Reactivity: Human | Form: PBS with 0.09% sodium azide, pH 7.3. |
| Host / Isotype: Recombinant | Background Information: CD98 is a 125-kDa type II membrane glycoprotein heterodimer composed of a 40-kDa non-glycosylated light chain (amino-acid transporter, encoded by the SLC7A5) and an 85-kDa glycosylated heavy chain (CD98hc, encoded by the SLC3A2) (PMID: 11507094). CD98hc also interacts with certain integrin b-subunits to regulate cell migration, survival, proliferation, and adhesion/polarity. CD98hc is overexpressed on the cell surface of many cancers and increased CD98hc expression is associated with the development and progression of tumors.(PMID:25084765). Molecular orientation studies have demonstrated that the C-terminal tail of human CD98 (hCD98), which contains a PDZ-binding domain, is extracellular (PMID: 18625289). |
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